Translational repression using BIV Tat peptide-TAR RNA interaction in mammalian cells.
نویسندگان
چکیده
We developed a strategy to create novel genetically encoded switches based on translational repression. We illustrated its efficacy by incorporating two copies of an RNA hairpin in the 5'-untranslated region (UTR) of a target mRNA and demonstrating 7-fold translational repression upon expression of a ligand - the BIV Tat peptide.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 67 شماره
صفحات -
تاریخ انتشار 2013